Tag «research projects»

Chemists from HSE University and the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) have developed a new method for synthesising amides, essential compounds in drug production. Using a ruthenium catalyst and carbon monoxide under precisely controlled reaction conditions, they successfully obtained the target product without by-products or complex purification steps. The method has already been tested for synthesising a key component of Vorinostat, a drug used to treat T-cell lymphoma. This approach could lower the cost of the drug by orders of magnitude. The paper has been published in the Journal of Catalysis. The study was supported by the Russian Science Foundation.

An international team including scientists from HSE University has investigated the brain's ability to comprehend hidden meanings in spoken messages. Using fMRI, the researchers found that unambiguous meanings activate brain regions involved in decision-making, whereas processing complex and ambiguous utterances engages regions responsible for analysing context and the speaker's intentions. The more complex the task, the greater the interaction between these regions, enabling the brain to decipher the meaning. The study has been published in NeuroImage.

Specialists at the HSE Faculty of Computer Science and Sber AI Lab have developed a geometric oversampling technique known as Simplicial SMOTE. Tests on various datasets have shown that it significantly improves classification performance. This technique is particularly valuable in scenarios where rare cases are crucial, such as fraud detection or the diagnosis of rare diseases. The study's results are available on ArXiv.org, an open-access archive, and will be presented at the International Conference on Knowledge Discovery and Data Mining (KDD) in summer 2025 in Toronto, Canada.

Researchers at HSE University in Nizhny Novgorod have explored how technological advancements are transforming the ways in which people preserve the memory of the deceased and significant events. Digital technologies enable the creation of virtual memorials, the preservation of personal stories and belongings of the deceased, interaction with their digital footprint, and even the development of interactive avatars based on their online activity. However, these technologies not only evoke nostalgia and provide a sense of relief but can also heighten anxiety and fear, and delay the process of accepting loss. The study has been published in Chelovek (The Human Being). 

An international team of researchers, including scientists from the HSE Centre for Language and Brain, has identified the causes of impairments in expressing grammatical tense in people with aphasia. They discovered that individuals with speech disorders struggle with both forming the concept of time and selecting the correct verb tense. However, which of these processes proves more challenging depends on the speaker's language. The findings have been published in the journal Aphasiology.

Economists from HSE and RUDN University have analysed issues related to corporate digital transformation processes. The introduction of digital solutions into corporate operations reduces the number of patents in the field of green technologies by 4% and creates additional financial difficulties. However, if a company focuses on sustainable development and increases its rating in environmental, social, and governance performance (ESG), the negative effects decrease. Moreover, when the ESG rating is high, digitalisation can even increase the number of patents by 2%. The article was published in Sustainability.

A team of Russian researchers has synthesised a novel compound for boron neutron capture therapy (BNCT), a treatment for advanced cancer that uses the boron-10 isotope. The compound exhibits low toxicity, excellent water solubility, and eliminates the need for administering large volumes. Most importantly, the active substance reaches the tumour with minimal impact on healthy tissues. The study was published in the International Journal of Molecular Sciences shortly before World Cancer Day, observed annually on February 4.

Scientists have discovered significant structural differences in the brain's pathways, tracts, and thalamus between children with autism and their neurotypical peers, despite finding no functional differences. The most significant alterations were found in the pathways connecting the thalamus—the brain's sensory information processing centre—to the temporal lobe. Moreover, the severity of these alterations positively correlated with the intensity of the child's autistic traits. The study findings have been published in Behavioural Brain Research.